A brand new drug might be more effective at preventing HIV than current methods.
Many people take daily oral antiretroviral medication—known as PrEP (pre-exposure prophylaxis)—to protect themselves from catching HIV, but according to a new paper in the New England Journal of Medicine, a twice-yearly injection is “significantly more effective than the daily oral PrEP.”
This drug, Lenacapavir, resulted in a 96 percent reduced risk of infection overall if taken once every 6 months, according to a recent Gilead-funded clinical trial led by physicians at Emory University and Grady Health System…Click Here To Continue Reading>> …Click Here To Continue Reading>>
“Lenacapvir, which is injected under the skin every 6 months, provided 96 percent protection from acquiring new HIV infection,” study lead author Colleen Kelley, a professor in the School of Medicine at Emory University and co-director of the Emory Center for AIDS Research, told Newsweek.
“Once FDA approved, this will be an incredible new option for people to use as HIV pre-exposure prophylaxis (HIV PrEP) as it is much easier to take than currently available HIV PrEP options, which include daily oral pills and injections every two months.
“In the trial, Lenacapavir was 89 percent better than oral PrEP. The nuance here is adherence. If people take oral PrEP every day, it is also highly effective. But many people, including those in the trial, are not able to take it every day, and the efficacy drops off. Getting injections means you don’t have to take a pill every day,” she said.
Stock image of a man getting an injection (main) and the HIV virus (inset). A new injection taken twice a year appears to be more effective than current PrEP at protecting against HIV.
PrEP works by preventing HIV from establishing an infection in your body if you’re exposed to the virus. HIV infects the body by attacking CD4 cells (a type of immune cell), inserting its genetic material, and replicating itself. PrEP medications contain antiretroviral drugs that interfere with this process.
Two oral PrEP medications have been approved by the U.S. Food and Drug Administration (FDA)—Truvada and Descovy—and one injection drug called Apretude that must be taken once every two months.
“PrEP reduces the risk of getting HIV from sex by about 99 percent when taken as prescribed. Although there is less information about how effective PrEP pills are among people who inject drugs, we know that PrEP pills reduce the risk of getting HIV by at least 74 percent when taken as prescribed,” the CDC says.
If not taken as prescribed, these drugs are less effective at protecting against HIV.
“All HIV PrEP are medications that work against the virus, called antiretrovirals. PrEP is the concept of taking these antiretroviral medications before possible HIV exposure during sexual intercourse to prevent infection,” Kelley said.
“This is similar to malaria prophylaxis for travelers—you take medications that are active against malaria when you travel to prevent getting malaria. Another good corollary is contraceptives for prevention of pregnancy. READ FULL STORY HERE>>>CLICK HERE TO CONTINUE READING>>>
This new drug, Lenacapvir, was seen to be more effective than oral Truvada PrEP overall because it doesn’t require the regimented consistency of taking the medication every day.
According to the paper, in the Phase III clinical trial comparing the effectiveness of Truvada and Lenacapavir, two out of 2,179 people in the the Lenacapavir group acquired HIV. Nine out of 1,086 people in the Truvada group were infected.
“Oral PrEP requires that people adhere to the medication over a long period of time. We have seen in countless studies that adherence to oral PrEP decreases over time, and some people have difficulties taking oral PrEP every day due to their life circumstances,” Kelley said.
“Unfortunately, the populations that have challenges taking daily oral PrEP over the long term are the same populations affected by health disparities and who experience increased rates of new HIV diagnoses.”
Over half of new HIV infections in the United States in 2022 were in cisgender gay men, 70 percent of whom were Black or Hispanic, the paper said.
“We are not reaching everyone we need to reach with our current HIV prevention interventions, such as those who are disproportionately impacted by HIV and health care disparities,” Kelley said in a statement. “For people that are unable to take the daily oral pills, the injectable agents can really give incredible efficacy and be a game changer in helping them stay HIV negative.”
“This is a considerable and profound advancement in medicine,” she said.
The Phase III trial has now been submitted to the FDA, and the researchers hope the drug may be approved for use as soon as 2025.
“The results of this study add to the armamentarium of novel tools for HIV prevention. Long acting antiretrovirals offer new hope for those who are not able to take oral medications,” Carlos del Rio, chair of the Department of Medicine at Emory University School of Medicine and co-director of the Emory Center for AIDS Research, said in the statement.
“The challenge is now to roll out and make these tools available and accessible in an equitable way— only then we will see new HIV infections dramatically decreased locally and globally.”
Have you ever given any thought to what would happen to your body if you continually subjected it to the effects of drinking hot water? When everything is taken into account, we are aware that water is important for the body to keep adequately hydrated and that it accounts for sixty percent of the human adult body (via USGS). Water makes up sixty percent of the human adult body. Who would have thought, though, that the temperature at which you consume it plays a role in the kinds of health benefits you gain from it?
However, drinking water that has been brought to a boil on a frequent basis offers a variety of additional health benefits, which your body may be prevented from taking advantage of if you drink cold water instead of water that has been brought to a boil. People have a propensity, when they think about drinking water, to picture themselves in a position in which they are sipping some water that is really cold while basking in the warmth of the late spring sun or relishing in the virus-like sensation of it after a particularly tough twisting class. This is because people have a tendency to picture themselves in scenarios in which they are partaking in activities that involve extreme temperatures. Drinking warm water first thing in the morning is recommended by medical professionals, as stated by Stella Metsovas, a professional nutritionist, who explains why this is the case. Medical Daily has been provided with this information. In point of fact, and to some degree one is taken aback by this revelation, access to this kind of information has been available for a significant amount of time now. According to Reader’s Digest, both Chinese and Indian physicians encourage drinking this steaming hot beverage first thing in the morning to get the most out of the day due to the many excellent benefits it has on one’s health. This is because traditional Chinese medicine and Indian medicine both believe that drinking this beverage in the morning helps one get the most out of the day.
Therefore, would you be so kind as to elaborate on what you mean by that? If you drink hot water on a regular basis, your body will experience these effects, which are something that may be expected.
In this difficult environment, there is a clear approach for being able to stretch less, and it all starts with establishing a daily appreciation for water. This is the first step in the process. Dietitian Amanda Carlson, who is also a qualified dietitian, is of the opinion that individuals can benefit from keeping an adequate level of hydration in order to experience reduced levels of anxiety. If you don’t give your body the liquids it needs, you’re adding extra weight to it, and your body will react to this by acting erratically.
According to Healthline, consuming hot water reduces the activity of your focus sensory system, which is responsible for determining how your brain reacts when it is subjected to pressure. According to the American Psychological Association, not getting enough water can cause confusion in the central nervous system, which can trigger a vicious loop that never comes to an end. It is actually easier to become dehydrated when you are under pressure, as your pulse will be higher than normal, and you will be breathing more actively than usual, says Renee Melton, MS, RD, LD, who is the head of nutrition at Sensei. This is because your pulse will be higher when you are under strain. WebMD received this information from another source. Therefore, if you truly want to get rid of the problem the next time it comes up, you might want to consider the alternative of continuously drinking hot water.
Regularly consuming water that has been heated to a boil has the ability to reduce the amount of physical pain and suffering that individual is experiencing.
Shaving may be a time-consuming and occasionally painful activity. If you’re seeking an easy way to remove face and body hair, Coca-Cola could be the answer. Here’s how to use this famous soft drink to remove hair without discomfort and why it works.
Why Coca-Cola?
Coca-Cola includes a combination of ingredients that can weaken hair follicles and facilitate hair removal. The carbonation and acidity in Coca-Cola combine to break down hair, making it easier to remove…Click Here To Continue Reading>> …Click Here To Continue Reading>>
How to Use Coca-Cola for Hair Removal
Ingredients:
1 can of Coca-Cola
Cotton pads
A small bowl
For illustrative purposes only.
Instructions:
1. Prepare the Solution:
Pour a can of Coca-Cola into a small basin.
2. Application:
Soak a cotton pad with Coca-Cola.
Apply the moistened cotton pad to the region with excess hair. Make sure the area is completely covered.
3. Let it Sit:
Allow the Coca-Cola to settle on your skin for approximately 15-20 minutes. This allows the carbonation and acidity to gradually damage the hair follicles.
Depending on the thickness of the hair, you may need to repeat this step several times. With regular application, you should see a reduction in hair growth.
For illustrative purposes only.
Benefits of Using Coca-Cola for Hair Removal
1. Pain-Free:
Compared to traditional methods like waxing or plucking, utilizing Coca-Cola is painless and gentle on the skin.
2. Cost-Effective:
Coca-Cola is inexpensive and widely available, making it an affordable option for hair removal.
3. Convenient:
This method may be done at home quickly and easily, with no special equipment or expert services required.
4. Decreases Hair Growth:
Hair follicle weakening over time might result in lower hair growth, making upkeep easier.
Conclusion
Using Coca-Cola for hair removal may seem unorthodox, but it is a painless and cost-effective alternative to typical techniques. With consistent usage, you can get smoother, hair-free skin without the inconvenience of shaving or the discomfort of waxing. Give it a shot and see the startling results for yourself!
Are you tired of dealing with skin imperfections like wrinkles, blemishes, melasma, moles, and warts? Look no further! We have a natural and effective solution for you – banana peels combined with baking soda.
Why Banana Peels and Baking Soda?
Banana Peels: These peels are not just food waste! They are actually packed with antioxidants, vitamins, and minerals that can nourish and revitalize your skin.
Scrape the inner white part of the banana peel with a spoon and collect about 2 tablespoons of the material.
In a small bowl, mix the banana peel paste with the baking soda until a smooth paste forms.
Application
Thoroughly clean and dry the area of skin where you intend to apply the mixture.
Apply the paste directly to the areas affected by wrinkles, blemishes, melasma, moles, or warts.
Leave the mixture on for about 15-20 minutes.
Rinse Off
Wash off the paste with lukewarm water. Be gentle to your skin while washing to avoid any irritation.
Moisturize
After drying your skin, apply a gentle moisturizer to keep your skin hydrated and protected.
Tips for Best Results
Frequency of Use: To see significant improvements, use this treatment two to three times a week. Consistent application is key!
Patch Test: Before applying the mixture broadly, always perform a patch test on a small area of skin, especially if you have sensitive skin.
Sun Protection: Protect your skin from the sun, especially after using this treatment, as the skin may be more sensitive to UV rays.
Precautions
If you have moles or warts, it’s important to have them checked by a healthcare provider before trying any home treatments.
Baking soda can be drying and may irritate sensitive skin. If you experience any redness, itching, or discomfort, discontinue use and consult with a dermatologist.
